Switch medication from Pimozide to Lurasidon.
- Day 1-7: gradually reduce the dose of pimozide to 50% of the dose.
- Day 8-14: gradually reduce the dose of pimozide to 0% of the dose
- Day 14: stop administration of pimozide.
- Day 1-7: start administration of lurasidon in a dose of 40 mg/day.
- Day 8-14: increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable.
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.
- McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.
- Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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