* '''Before day 1:''' gradually reduce dosage of sertraline to a maximum of 100 mg/day, when this dosage is > 100 mg/day. {{TCAdecrease25p3d}}* '''Day 1:''' reduce dosage of sertraline to 50 mg/day.* '''Day 8:''' reduce dosage of sertraline to 25 mg/day.* '''Day | start = {{StartAgomelatine|15:''' stop administration of sertraline.}}| start info= * '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.* '''Day 15:''' continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day. }}
