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| from = sertraline
| to = trazodone
| stop = * '''Before day 0:''' gradually reduce dosage of sertraline to a maximum of 50 mg/ day{{StopSSRI, when this dosage is > 50 mg/day. * '''Day 1:''' reduce dosage of sertraline to 25 mg/day.* '''Day 8:''' stop administration of sertraline.SNRI}}| start = {{StartAntidepressant}}* No wash-out period is needed. | info =* Start Safe target dose trazodone the next day in normal dosage of as antidepressant = 150 mg/day.* If necessary, increase the dosage of trazodone to a maximum of 400 mg/day.| info = * Sertraline dose-dependently slows the metabolism of trazodone via CYP2D6, so caution is necessary.{{theorSS}}
}}
