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| from = sertraline
| to = vortioxetine
| stop = * '''Before day 1:''' gradually reduce dosage of sertraline to a maximum of 15 mg/day{{StopSSRI, when this dosage is > 50 mg/day. * '''Day 1:''' when a dosage of 50 mg/day is reached, stop administrationSNRI}}| start = {{StartAntidepressant}}* A wash-out period is not necessary.| info =* '''Day 1:''' start administration of Safe target dose vortioxetine in a dosage of = 10 mg/day.| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}* Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>
}}
