Changes

* Clozapine is generally considered to be more effective than other antipsychotic drugs. Clozapine is often used in treatment-resistant schizophrenia (poor treatment response to 2 or more antipsychotic drugs). So a switch from clozapine to another antipsychotic drug could cause problems regarding effectiveness.<ref> McEvoy J P et al., [http://ajp.psychiatryonline.org/cgi/content/full/163/4/600 Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment]. Am J Psychiatry. 2006;163:600–610.</ref> <ref> Lewis S W et al., [http://schizophreniabulletin.oxfordjournals.org/cgi/content/abstract/32/4/715 Randomized Controlled Trial of Effect of Prescription of Clozapine Versus Other Second-Generation Antipsychotic Drugs in Resistant Schizophrenia]. Schizophrenia Bulletin vol.32 no.4 pp.715–723,2006. </ref> <ref> Agid O, Kapur S, Remington G, [http://www.ncbi.nlm.nih.gov/pubmed/18764724 Emerging drugs for schizophrenia]. Expert Opin Emerg Drugs. 2008 Sep;13(3):479-95.</ref>