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* Hypericum induces enzymes of the [[wp:Cytochrome P450 reductase|CYP P-450 ]] type and P-gp type.* Hypericum might have [[wp:Monoamine oxidase inhibitor|MAO-inhibiting ]] and/or [[wp:COMT inhibitor|COMT-inhibiting ]] properties.* Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.<ref name ="Wurglics2006">{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M.Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.}}</ref>