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Tranylcypromine-agomelatine

541 bytes removed, 15:41, 4 August 2023
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* '''Before day 1:''' gradually reduce dosage of tranylcypromine to a maximum of 40 mg/day, when this dosage is > 40 mg/day. * '''Day 1:''' reduce dosage of tranylcypromine to 20 mg/day.* '''Day 8:''' reduce dosage of tranylcypromine to 10 mg/day.* '''Day 15:''' stop administration of tranylcypromine.{{stopTranyl}}
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* '''Day 15-28:''' a wash-out period of two weeks is necessary.* '''Day 29:''' start administration of agomelatine in a dosage of 25 mg/day.* If necessary, increase dosage of agomelatine to 50 mg/day. {{startAgomelatine}}
| info =
{{Tcrestore}}<ref name="informatorium">{{KNMP|tranylcypromine}}</ref> * Tranylcypromine has to be phased out to avoid withdrawal symptoms.* Because tranylcypromine is a irrivesible <ref>Dr. M.J.Blom et al. (2009) Gebruik van klassieke MAO inhibitor, the activity of MAO enzymes will be normal again after two weeks.-remmers</ref>* Occurrence of the serotonin syndrome is possible without a wash-out period.{{review}}
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