| to = agomelatine
| stop =
* '''Before day 1:''' gradually reduce dosage of tranylcypromine to a maximum of 40 mg/day, when this dosage is > 40 mg/day. * '''Day 1:''' reduce dosage of tranylcypromine to 20 mg/day.* '''Day 8:''' reduce dosage of tranylcypromine to 10 mg/day.* '''Day 15:''' stop administration of tranylcypromine.{{Dec25p3d}}
| start =
* '''Day 15-28:''' a wash-out period of two weeks is necessary.* '''Day 29:''' start administration of agomelatine in a dosage of 25 mg/day.* If necessary, increase dosage of agomelatine to 50 mg/day. {{Inc25p3do50pw}}
| info =
* Tranylcypromine has to be phased out to avoid withdrawal symptoms.
* Because tranylcypromine is a irrivesible MAO inhibitor, the activity of MAO enzymes will be normal again after two weeks.
* Occurrence of the serotonin syndrome is possible without a wash-out period.{{review}}
}}
