Tranylcypromine-clomipramine
From Psychiatrienet
{{Drugswitch | from = tranylcypromine | to = clomipramine | stop =
- Day 1: decrease the original dose with about 25% every 3 days.
- Day 9: stop administration of tranylcypromine.
| start =
- Day 23: Start and increase the dose with about 25% of the target dose every 3 days. [1]
|caveat =
- Occurrence of the serotonin syndrome is possible without wash-out period.
| info =
- After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes[1]
- Tranylcypromine has to be phased out to avoid withdrawal symptoms.[2]
- Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
