| to = hypericum
| stop =
* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week. * When a dosage of 10 mg/day is reached, stop administration.{{Dec25p3d}}
| start =
* '''Day 1-15:''' a wash-out period of at least two weeks is necessary.{{Inc25p3do50pw}}<ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration. Br J Clin Pharmacol. 2008 May;65(5):701-7.}}</ref><ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.}}</ref><ref name="informatorium">{{KNMP|tranylcypromine}}</ref>
* '''Day 16:''' start hypericum after this period in a dosage of 300 mg three times a day (900 mg/day).
| info =
* Occurrence of the serotonin syndrome is possible without a wash-out period.{{Tcrestore}}* The wash-out period is necessary for the MAO enzymes to restore their function.}}
