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| from = trazodone
| to = duloxetine
| stop = * '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 100-150 mg/day{{StopSSRI, when this dosage is > 200 mg/day. * '''Day 1:''' reduce dosage of trazodone to 75 mg or maintain on 100 mg/day.* '''Day 8:''' stop administration of trazodone.SNRI}}| start = {{StartAntidepressant}}* A wash-out period is not necessary, but care is needed.| info =* '''Day 8:''' start administration of Safe target dose duloxetine in a normal dosage of = 60 mg/day.| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}* Duloxetine is a strong inhibitor of CYP2D6, which metabolizes trazodone.}}
