Switch medication from trazodone to duloxetine.
- Before day 1: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
- Day 1: reduce dosage of trazodone to 100 mg/day.
- Day 3: reduce dosage of trazodone to 50 mg/day.
- Day 8: stop administration of trazodone.
- A wash-out period is not necessary, but care is needed.
- Day 9: start administration of duloxetine in a normal dosage of 60 mg/day.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Duloxetine is a strong inhibitor of CYP2D6, which metabolizes trazodone.
- The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
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