Changes

Jump to: navigation, search

Trazodone-hypericum

382 bytes added, 12:37, 4 November 2015
no edit summary
| to = hypericum
| stop =
* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day. * '''Day 1:''' reduce dosage of trazodone to 75 mg/day.* '''Day 8:''' stop administration of trazodone.{{stopTrazodone}}
| start =
* ''' Day 8-15: ''' A wash-out washout period of one week is not necessary.* '''Day 115:''' simultaneously start administration of citalopram/escitalopram hypericum in a normal dosage of 20 300 mg three times a day (900 mg/day).<ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, respMorimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration. Br J Clin Pharmacol. 10 mg2008 May;65(5):701-7.}}</dayref><ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M.* Hypericum perforatum: a 'modern''Day 8herbal antidepressant:''' stop administration pharmacokinetics of trazodone and continue administration active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.}}</ref><ref>{{Pubmed|19593191|Derijks HJ, Janknegt R, Heerdink ER, De Koning FH, Krekels MM, Looij BJ, Egberts AC. Influence of citalopramantidepressant use on glycemic control in patients with diabetes mellitus: an open-label comparative study. J Clin Psychopharmacol. 2009 Aug;29(4):405-8.}}</ref><ref name="informatorium">{{KNMP|trazodon}}</escitalopram.ref>  
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{trazoTablet}}}}
editor
1,352
edits

Navigation menu