Trazodone-sertraline

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• Before day 0: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
• Day 1: reduce dosage of trazodone to 75-100 mg/day.
• Day 8: stop administration of trazodone.
• Day 8-13: wash-out period

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• Day 14: start administration of sertraline in a normal dosage of 50 mg/day.

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• Sertraline dose-dependently inhibits CYP2D6, which metabolizes trazodone.