* '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.* '''Day 1:''' reduce to a dosage of 75 mg/day to 37,5 mg/day.* '''Day 8:''' stop administration of venlafaxine {{TCAdecrease25p3d}}| start = {{StartAgomelatine|8}}* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day. * '''Day 8:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.}}
