Difference between revisions of "Venlafaxine-maprotiline"

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(Created page with '{{Drugswitch | from = venlafaxine | to = maprotiline | stop = * '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day. * '''Day 1:''' reduce a dosage o...')
 
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| to = maprotiline
 
| to = maprotiline
 
| stop =  
 
| stop =  
* '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
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{{downVenla}}
* '''Day 1:''' reduce a dosage of 75 mg/day to 37,5 mg/day.
 
 
| start =  
 
| start =  
* '''Day 1:''' simultaneously start administration of maprotiline in a low dosage of 25-75 mg/day.
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* '''Day 15:''' start administration of maprotiline in a low dosage of 25 mg/day.
* '''Day 8:''' stop administration of venlafaxine and continue administration of maprotiline.
 
 
| info =   
 
| info =   
* “Start low, go slow” is not required, but caution with this switch is necessary.
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* Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes maprotiline.}}
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}}

Revision as of 17:16, 17 July 2009

Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine
Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline

Switch medication from venlafaxine to maprotiline.[1] [2]

Nietinrijdenbord.png Stop venlafaxine
  • Day 1-14: gradually reduce dosage of venlafaxine to a maximum of 37,5 mg or 75 mg (slow release)/ day.
  • Day 15: stop administration of venlafaxine
Eenrichtingbord.png Start maprotiline
  • Day 15: start administration of maprotiline in a low dosage of 25 mg/day.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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