Changes

| from = Vortioxetine vortioxetine

{{Stopvortioxetine}}| stop start = {{StartAgomelatine|15}}* '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.* '''Day 7:''' stop administration of vortioxetine.| start info = * '''Day 8:''' start administration of agomelatine in a dosage of 25 mg/day. * '''Day 22:''' continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.References <ref name="agoswitchvortiswitch"> {{Pubmed|2019618724570588 |McAllister-Williams RH Katona et al. The use of New generation multi-modal antidepressants in clinical practice: focus on agomelatinevortioxetine for major depressive disorder. Hum Psychopharmacol. 2010 Mar 12014 2014 Feb 19;25(2)10:95349-10254}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref><ref name="Summary of Product Characteristics"> [http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002717/WC500159449.pdf Summary of Product Characteristics Vortioxetine]</ref>