Changes

| stop = {{downVenlastopVortioxetine}}

* '''Day 79:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day. * '''Day 1523:''' continue administration of agomelatine. If if necessary, increase dosage of agomelatine to 50 mg/day.<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref> |info = * References <ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref> <ref name="Summary of Product Characteristics"> [http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002717/WC500159449.pdf Summary of Product Characteristics Vortioxetine]</ref>