Changes

{{washout8-14}}* '''Day 815:''' start administration of duloxetine in a normal dosage of 30-60 mg/day.* '''Day 15{{Day22NoBloodlevelvortioxetine}}<ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants:''' increase the dosage of duloxetine if neededfocus on vortioxetine for major depressive disorder.2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref>

* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}* Duloxetine is a inhibitor of CYP2D6, which metabolizes vortioxetine.<ref>[[European Medicines Agency]] | SmPC Brintellix 5 mg. </ref>}}