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| from = vortioxetine
| to = duloxetine
| stop = * '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.* '''Day 7:''' stop administration of vortioxetine.{{StopSSRI,SNRI}}| start = * '''Day 8:''' start administration of duloxetine in a normal dosage of 30-60 mg/day.* '''Day 15:''' increase the dosage of duloxetine if needed.{{StartAntidepressant}}| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.<ref>[[European Medicines Agency]] | SmPC Brintellix 5 Safe target dose duloxetine = 60 mg. </ref>* Duloxetine is a inhibitor of CYP2D6, which metabolizes vortioxetine.<ref>[[European Medicines Agency]] | SmPC Brintellix 5 mg. </ref>{{theorSS}}}}
