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| from = vortioxetine
| to = duloxetine
| stop = * '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.* '''Day 8:''' stop administration of vortioxetine.{{StopSSRI,SNRI}}| start = {{washout8-14StartAntidepressant}}| info =* '''Day 15:''' start administration of Safe target dose duloxetine in a dosage of 30 = 60 mg/day.* {{Day22NoBloodlevelvortioxetinetheorSS}}| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Duloxetine is a inhibitor of CYP2D6, which metabolizes vortioxetine.<ref>[[European Medicines Agency]] | SmPC Brintellix 5 mg. </ref>}}
