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* A wash-out period of 2 weeks is necessary, because of CYP2D6-inhibition.{{Day22NoBloodlevelvortioxetine}}* '''Day 2223:''' start administration of fluoxetine in a normal dosage of 20 mg/day.
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. <ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref> }}
