| to = paroxetine
| stop =
* '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.* '''Day 7:''' stop administration of vortioxetine.{{stopVortioxetine}}
| start =
* A wash{{washout8-out period is not necessary, but care is needed.14}}* '''Day 815:''' start administration of paroxetine in a normal dosage of 10-20 mg/day.<ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref>
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}
* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }}
