Switch medication from Chlorpromazine to Olanzapine_LA.
- Day 1-4: approx. 75% of initial dose
- Day 5-8: approx. 50% of initial dose
- Day 9-12: approx. 25% of initial dose
- Day 13: stop
- Day 1: Start depot according general dosing advice
- It is safer first to switch to oral olanzapine and afterwards to olanzapine pamoate. See Switchtable
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.
- Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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