Combining-Aripiprazole-Lithium

Ariprazole Type Antipsychotic Group Atypical AP Other use moodstabilizer links EMEA abilify PubChem 60975 PubMed Ariprazole Kompas (Dutch) Ariprazole Wikipedia Ariprazole more info

Lithium Type moodstabilizer Group other links ATC-code N05AN01 Medscape Lithium PubChem 11125 PubMed Lithium Drugs.com lithium Kompas (Dutch) Lithium Wikipedia Lithium more info T1/2 12-48h administration O

Adding lithium to aripiprazole.

General information

• Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
• Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
• This combination may have additive side effects.

Start lithium

• Start lithium according to the general dosing advice.

Cave

• The concomitant administration of lithium with neuroleptic agents may increase the risk of extrapyramidal reactions and neurotoxicity.

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