Combining-Aripiprazole-Topiramate

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Ariprazole
Type Antipsychotic
Group Atypical AP
Other use moodstabilizer
links
EMEA abilify
PubChem 60975
PubMed Ariprazole
Kompas (Dutch) Ariprazole
Wikipedia Ariprazole
Topiramate
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX11
PubChem 5284627
PubMed Topiramate
Drugs.com topiramate
Kompas (Dutch) Topiramate
Wikipedia Topiramate

Adding topiramate to aripiprazole.

Infobord.png General information
  • Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
  • Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
  • This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects.
Eenrichtingbord.png Start topiramate
  • Start topiramate according general dosing advice.
  • Dose adaptation of aripiprazole could be necessary because of the enzym induction by topiramate.
Letopbord.png Cave
  • Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. [2]
  • Patients, particularly pediatric patients, should be monitored closely for evidence of decreased sweating and increased body temperature, especially in warm or hot weather.


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