Combining-Aripiprazole-Topiramate

Ariprazole Type Antipsychotic Group Atypical AP Other use moodstabilizer links EMEA abilify PubChem 60975 PubMed Ariprazole Kompas (Dutch) Ariprazole Wikipedia Ariprazole more info

Topiramate Type moodstabilizer Group anticonvulsant links ATC-code N03AX11 PubChem 5284627 PubMed Topiramate Drugs.com topiramate Kompas (Dutch) Topiramate Wikipedia Topiramate more info T1/2 21h bioavailability 50% administration O

Adding topiramate to aripiprazole.

General information

• Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
• Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
• This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects.

Start topiramate

• Start topiramate according general dosing advice.
• Dose adaptation of aripiprazole could be necessary because of the enzym induction by topiramate.

Cave

• Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity.
• Patients, particularly pediatric patients, should be monitored closely for evidence of decreased sweating and increased body temperature, especially in warm or hot weather.

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