Adding carbamazepine to ziprasidone.
- Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
- Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
- This combination of drugs may have possible synergistic effects.
- Induction of CYP3A4 by carbamazepine may modestly influence the plasma level of ziprasidone. Ziprasidone dose modifications are unlikely to be necessary in patients receiving potent CYP450 3A4 inducers.
- Start carbamazepine according to the general dosing advice.
- WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
- Farmacotherapeutisch Kompas; Toxicologie (dutch)
- Farmacotherapeutisch Kompas - carbamazepine (dutch)
- KNMP; Informatorium Medicamentorum 2015; Monografie "carbamazepine" (Dutch)
- Interactions between ziprasidone and carbamazepine on drugs.com
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