Combining-Ziprasidone-Topiramate

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Ziprasidone
Type Antipsychotic
Group Atypical AP
Other use Moodstabilizer
links
Medscape Ziprasidone
PubChem 60854
PubMed Ziprasidone
Wikipedia Ziprasidone
Topiramate
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX11
PubChem 5284627
PubMed Topiramate
Drugs.com topiramate
Kompas (Dutch) Topiramate
Wikipedia Topiramate

Adding topiramate to ziprasidone.

Infobord.png General information
  • Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
  • Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
  • Dose adaptation will be recommended for this combination.
  • This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects.
Eenrichtingbord.png Start topiramate
  • Start topiramate according general dosing advice.
Letopbord.png Cave
  • Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. [2]


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