Switch medication from escitalopram to trazodone.
- Before day 1: gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is >10 mg/day.
- Day 1: reduce dosage of escitalopram to a maximum of 5 mg/day.
- Day 8: stop administration of escitalopram.
- No wash-out period is needed.
- Day 9: start trazodone in a dosage of 100-150 mg/day.
- Day 16: if necessary, increase the dosage of trazodone to a maximum of 400 mg/day.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
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