Paliperidone SP-Paliperidone LP

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Paliperidone SP
Trevicta® = super long acting, 90 days
Type Antipsychotic
Group Atypical AP
links
PubChem 23724979
PubMed SP%22 Paliperidone SP
Kompas (Dutch) Paliperidone SP
Wikipedia Paliperidone SP
Paliperidone LP
Xeplion® = long acting, 30 days
Type Antipsychotic
Group Atypical AP
links
PubChem 23724979
PubMed LP%22 Paliperidone LP
Kompas (Dutch) Paliperidone LP
Wikipedia Paliperidone LP

Switch medication from Paliperidone_SP to Paliperidone_LP.[1] [2]

Nietinrijdenbord.png Stop Paliperidone_SP
  • Day 1: Last depot injection
Eenrichtingbord.png Start Paliperidone_LP

Start depot on the day you would normally have injected the next depot. Determine the dose of paliperidone LP (Xeplion ®) by dividing the dose of paliperidone SP (Trivecta ®) by 3,5. Administer monthly. Loading dose is not needed[3]


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Switches are based on information of the KNMP Informatorium medicamentorum: Paliperidone, accessibele at https://www.kennisbank.knmp.nl
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