Paroxetine-bupropion
From Psychiatrienet
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Switch medication from paroxetine to bupropion[1][2]
Stop paroxetine - Before day 1: If paroxetine dose is above 20mg/day gradually reduce dose to 20 mg/day
- Day 1: Decrease with about 25% of original dose every 3-4 days
Start bupropion- Day 1: start bupropion in a normal dosage of 150 mg/day.
- Day 8: if necessary increase bupropion dosage to 300 mg/day.
More information- Its possible to start bupropion before day 1, while reducing the dose of paroxetine to 20mg/day.
- Bupropion is a strong CYP2D6 inhibitor
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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