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* '''Day 1-7:''' a wash-out period of at least one week is necessary.
* '''Day 8:''' start venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.
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* By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.
* Bupropion slows the metabolism of venlafaxine by CYP2D6.}}
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