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* By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.
* Bupropion slows the metabolism of venlafaxine by CYP2D6.}}<ref> Stöllberger C, Huber JO, Finsterer J, [http://www.ncbi.nlm.nih.gov/pubmed/16096514?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum Antipsychotic drugs and QT prolongation]. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.</ref>
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