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* By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.
* Bupropion slows the metabolism of venlafaxine by CYP2D6.<ref> Stöllberger C, Huber JO, Finsterer JKennedy et al, [http://www.ncbi.nlm.nih.gov/pubmed/1609651411926715?ordinalpos=611&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum Antipsychotic drugs and QT prolongation]. Int J Clin Psychopharmacol. 2005 SepPsychiatry 2002 March;2063(53):243181-516.</ref>
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