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* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
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* Coadministration with risperidone may alter the serum concentrations of valproic acid, although data are conflicting.* Start according to the general dosing advice. Monitoring of the pharmacologic response and serum valproate levels is recommended. <ref name="drugscom">{{DRUGSCOM|olanzapine}}</ref>
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* Antipsychotics lower the seizure threshold and may antagonise the anticonvulsant effect of valproate. <ref name=”bazire”> Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
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