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Created page with '{{Drugcombi | base = risperidone | add = valproic acid | info = * Risperidone is principally metabolized by CYP2D6 to an active metabolite. * Valproic acid is principally metabo...'
{{Drugcombi
| base = risperidone
| add = valproic acid
| info =
* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
* Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Coadministration with risperidone may alter the serum concentrations of valproic acid, although data are conflicting.
* Start valproic acid according to the general dosing advice.
| cave =
* Dose-related generalised oedema is reported. <ref> {{Pubmed|9921707|Sanders and Lehrer, Edema associated with addition of risperidone to valproate treatment. J Clin Psychiatry. 1998 Dec;59(12):689-90.}}</ref>
* Antipsychotics lower the seizure threshold and may antagonise the anticonvulsant effect of valproate. <ref name=”bazire”> Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
}}
| base = risperidone
| add = valproic acid
| info =
* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
* Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Coadministration with risperidone may alter the serum concentrations of valproic acid, although data are conflicting.
* Start valproic acid according to the general dosing advice.
| cave =
* Dose-related generalised oedema is reported. <ref> {{Pubmed|9921707|Sanders and Lehrer, Edema associated with addition of risperidone to valproate treatment. J Clin Psychiatry. 1998 Dec;59(12):689-90.}}</ref>
* Antipsychotics lower the seizure threshold and may antagonise the anticonvulsant effect of valproate. <ref name=”bazire”> Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
}}
