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* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
* Valproic acid There is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases. * This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for little or no data available about this combination.
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* Coadministration with risperidone may alter the serum concentrations of valproic acid, although data are conflicting.
