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* The combination of lithium and valproate appears to be well tolerated and effective in treating bipolar illness.<ref name="freeman"/>
* Addition of valproate to lithium has been recognized as a first-line treatment for mania that is refractory to lithium monotherapy.<ref name="freeman"/>
* The combination addition of valproate is most effective for patients with rapid cycling or mixed episodes. <ref name="freeman"/>
* This combination may be synergistic.<ref name="freeman"/>
* Lithium’s pharmacokinetics are not changed by valproate.<ref name="freeman"/>
