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| add = valproic acid
| info =
* Lithium and valproic acid are the most commonly usedmood-stabilizing agents.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref> * The combination of lithium and valproate appears to be well tolerated and effective in treating bipolar illness.<ref name="freeman"/>* Addition of valproate to lithium has been recognized as a first-line treatment for mania that is refractory to lithium monotherapy.<ref name="freeman"/> * The combination is most effective for patients with rapid cycling or mixed episodes. * This combination may be synergistic.<ref name="freeman"/>* Lithium’s pharmacokinetics are not changed by valproate.<ref name="freeman"/>* There may be additive adverse reactions due to this combination, such as weight gain, sedation, gastrointestinal complaints, and tremor.<ref name="freeman"/>
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* Start valproic acid according to the general dosing advice.
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