* Start paroxetine the next day in normal low dosage of 20 10 mg/day.

* Bupropion By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually) it is assured that all bupropion has left the body and no drug interactions occur. * Bupropion slows the metabolismof paroxetine by CYP2D6.}}