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* When a dosage of 150 mg/day is reached, stop administration.
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* No '''Day 1-7:''' a wash-out period of at least one week is needednecessary. * Start '''Day 8:''' start paroxetine the next day in low dosage of 10 mg/day.
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* By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.
* Bupropion slows the metabolismof paroxetine by CYP2D6.}}