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• Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
• If necessary, increase dosage of agomelatine to 50 mg/day.

McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102