Difference between revisions of "Amitriptyline-fluoxetine"
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{{Drugswitch | {{Drugswitch | ||
| from = amitriptyline | | from = amitriptyline | ||
| − | | to = fluoxetine | + | | to = fluoxetine |
| stop = | | stop = | ||
| − | + | {{TCAdecrease25p3d}} | |
| − | |||
| − | |||
| start = | | start = | ||
| − | * '''Day | + | * '''Day 6 and after''': At approximately 50-25% of the original TCA dosering start fluoxetine at 100% of the target dose. |
| − | * ''' | + | * ''' After 3 weeks:''' If necessary, gradually increase dosage of fluoxetine. |
| + | |||
| info = | | info = | ||
| − | * | + | * Safe target dose fluoxetine = 20 mg |
| − | * Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) | + | * Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) which metabolizes nortriptyline, (a metabolite of amitriptyline). |
| + | }} | ||
Latest revision as of 12:17, 8 March 2024
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Switch medication from amitriptyline to fluoxetine.[1] [2]
Stop amitriptyline - Day 1: Decrease with about 25% of the original dose per 3 days.
Start fluoxetine- Day 6 and after: At approximately 50-25% of the original TCA dosering start fluoxetine at 100% of the target dose.
- After 3 weeks: If necessary, gradually increase dosage of fluoxetine.
More information- Safe target dose fluoxetine = 20 mg
- Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) which metabolizes nortriptyline, (a metabolite of amitriptyline).
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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