Difference between revisions of "Citalopram-imipramine"
From Psychiatrienet
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| to = imipramine | | to = imipramine | ||
| stop = | | stop = | ||
| − | * ''' | + | * '''Before day 1:''' gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day. |
* '''Day 1:''' reduce dosage of citalopram/escitalopram to a maximum of 10 mg/day resp. 5 mg/day. | * '''Day 1:''' reduce dosage of citalopram/escitalopram to a maximum of 10 mg/day resp. 5 mg/day. | ||
* '''Day 8:''' stop administration of citalopram/escitalopram. | * '''Day 8:''' stop administration of citalopram/escitalopram. | ||
Revision as of 15:09, 11 September 2009
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Switch medication from citalopram to imipramine.[1] [2]
Stop citalopram - Before day 1: gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day.
- Day 1: reduce dosage of citalopram/escitalopram to a maximum of 10 mg/day resp. 5 mg/day.
- Day 8: stop administration of citalopram/escitalopram.
Start imipramine- Day 8: no wash-out period is needed. Start administration of imipramine in a low dosage of 25 mg/day.
- Day 15: increase dosage of imipramine.
- Start low, go slow.
More information- The same applies to escitalopram.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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