* '''Before day 01:''' gradually reduce dosage of maprotiline to a maximum of 75 mg/day.

* '''Day 37:''' reduce dosage of maprotiline to 25 mg/day.* '''Day 14:''' stop dosage of maprotiline.

Caution is necessary.* '''Day 17:''' simultaneously start administration of mianserine in a low dosage of 30 mg/day.* '''Day 814:''' stop administration of maprotiline and continue administration of mianserine. * If necessary, increase dosage of mianserine. }}