Difference between revisions of "Tranylcypromine-agomelatine"
From Psychiatrienet
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| to = agomelatine | | to = agomelatine | ||
| stop = | | stop = | ||
| − | * '''Before day | + | * '''Before day 1:''' gradually reduce dosage of tranylcypromine to a maximum of 40 mg/day, when this dosage is > 40 mg/day. |
* '''Day 1:''' reduce dosage of tranylcypromine to 20 mg/day. | * '''Day 1:''' reduce dosage of tranylcypromine to 20 mg/day. | ||
* '''Day 8:''' reduce dosage of tranylcypromine to 10 mg/day. | * '''Day 8:''' reduce dosage of tranylcypromine to 10 mg/day. | ||
Revision as of 15:25, 17 November 2009
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Switch medication from tranylcypromine to agomelatine.[1] [2]
Stop tranylcypromine - Before day 1: gradually reduce dosage of tranylcypromine to a maximum of 40 mg/day, when this dosage is > 40 mg/day.
- Day 1: reduce dosage of tranylcypromine to 20 mg/day.
- Day 8: reduce dosage of tranylcypromine to 10 mg/day.
- Day 15: stop administration of tranylcypromine.
Start agomelatine- Day 15-28: a wash-out period of two weeks is necessary.
- Day 29: start administration of agomelatine in a dosage of 25 mg/day.
- If necessary, increase dosage of agomelatine to 50 mg/day.
More information- Tranylcypromine has to be phased out to avoid withdrawal symptoms.
- Because tranylcypromine is a irrivesible MAO inhibitor, the activity of MAO enzymes will be normal again after two weeks.
- Occurrence of the serotonin syndrome is possible without a wash-out period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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