Difference between revisions of "Nortriptyline-citalopram"
From Psychiatrienet
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| to = citalopram | | to = citalopram | ||
| stop = | | stop = | ||
| − | * '''Before day | + | * '''Before day 1:''' gradually reduce dosage of nortriptyline to a maximum of 100 mg/day. |
* '''Day 1:''' reduce dosage of nortriptyline to 50 mg/day. | * '''Day 1:''' reduce dosage of nortriptyline to 50 mg/day. | ||
* '''Day 3:''' reduce dosage of nortriptyline to 25 mg/day. | * '''Day 3:''' reduce dosage of nortriptyline to 25 mg/day. | ||
Revision as of 15:33, 17 November 2009
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Switch medication from nortriptyline to citalopram.[1] [2]
Stop nortriptyline - Before day 1: gradually reduce dosage of nortriptyline to a maximum of 100 mg/day.
- Day 1: reduce dosage of nortriptyline to 50 mg/day.
- Day 3: reduce dosage of nortriptyline to 25 mg/day.
Start citalopram- Day 1: simultaneously start administration of citalopram/escitalopram in a normal dosage of 20 mg/day, resp. 10 mg/day.
- Day 8: stop administration of nortriptyline and continue administration of citalopram/escitalopram.
More information- Citalopram/escitalopram are a weak inhibitor of CYP2D6, which metabolizes nortriptyline.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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