Difference between revisions of "Bupropion-imipramine"
From Psychiatrienet
| Line 3: | Line 3: | ||
| to = imipramine | | to = imipramine | ||
| stop = | | stop = | ||
| − | * Gradually reduce dosage of bupropion to a maximum of 150 mg/ day. | + | * '''Before day 1:''' Gradually reduce dosage of bupropion to a maximum of 150 mg/ day. |
| − | * | + | * '''Day 1:''' Stop administration of bupropion |
| start = | | start = | ||
* '''Day 1-3:''' start administration of imipramine the next day in a low dosage of 25 mg/day. | * '''Day 1-3:''' start administration of imipramine the next day in a low dosage of 25 mg/day. | ||
Revision as of 14:35, 27 November 2009
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Switch medication from bupropion to imipramine.[1] [2]
Stop bupropion - Before day 1: Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
- Day 1: Stop administration of bupropion
Start imipramine- Day 1-3: start administration of imipramine the next day in a low dosage of 25 mg/day.
- Day 4: increase dosage of imipramine to 50 mg/day and continue slowly increasing the dosage depending on the condition of the patient.
More information- Bupropion slows the metabolism of imipramine via CYP2D6.
- Caution is necessary at the start of administration of imipramine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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