Difference between revisions of "Combining-Gabapentin-Topiramate"
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Adding topiramate to gabapentin.
General information- Gabapentin is eliminated unchanged by the kidney for 100%.
- Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
- Gabapentine is eliminated unchanged by the kidney for 100%. Changes in the rate of excretion can cause unwanted effects.
- Topiramate induces CYP3A4 and is an inhibiter of CYP2C19.
- This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation is recommended for this combination. [2]
Start topiramate- Start topiramate according to the general dosing advice.
- ↑ 1.0 1.1 1.2 Farmacotherapeutisch Kompas - gabapentine (dutch)
Cite error: Invalid
<ref>tag; name "ftk" defined multiple times with different content Cite error: Invalid<ref>tag; name "ftk" defined multiple times with different content - ↑ Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
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