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Combining-Carbamazepine-Olanzapine

211 bytes removed, 15:21, 21 April 2010
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| add = olanzapine
| info =
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
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* Carbamazepine can reduce olanzapine serum concentration, possible below therapeutic range. <ref> {{Pubmed|9860152|Lucas RA et al. A pharmacokinetic interaction between carbamazepine and olanzapine: observations on possible mechanism. Eur J Clin Pharmacol 1998;54:639-43}}</ref><ref>{{drugscominteract|carbamazepine-with-zyprexa-497-0-1744-1113|carbamazepine|olanzapine}}</ref>
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